Tirzepatide B12 Protocol

Physician Services›Weight Loss›Tirzepatide + B-12
TWMD COMPOUNDED PHYSICIAN RX
Dual GLP-1 / GIP Agonist · Physician Services

Tirzepatide + B-12

Compounded Injectable · Dual Receptor Agonist · Progressive Dosing Protocol
How this works: Clicking any option below takes you to the TeleWellnessMD® platform where a licensed medical provider reviews your information. An initial consultation is required. Compounded medications are not FDA-approved as safe and effective for the treatment of any disease or condition.
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About This Protocol

Tirzepatide is a dual GIP and GLP-1 receptor agonist — a compound that activates both the glucose-dependent insulinotropic polypeptide receptor and the glucagon-like peptide-1 receptor simultaneously. This dual mechanism distinguishes it from single-receptor GLP-1 agonists. This protocol is compounded with Cyanocobalamin (B-12) to support energy metabolism.

This is a physician-supervised compounded medication available exclusively through licensed TeleWellnessMD® medical providers. The physician evaluates each patient individually. Not all patients will qualify.

Dual Receptor Mechanism
GIP receptors are expressed in the pancreas, adipose tissue, and bone. When activated alongside GLP-1 receptors, they produce complementary effects on insulin secretion, glucagon suppression, and gastric motility. According to clinical research published in the New England Journal of Medicine (2022), dual agonism has been studied in the context of metabolic function.
GLP-1 Receptor Component
GLP-1 receptors are expressed in the pancreas, brain, and gastrointestinal tract. When activated, they stimulate glucose-dependent insulin secretion and slow gastric emptying — affecting signals that regulate appetite and satiety.
Progressive Dosing
Protocols using dual receptor agonists typically begin at lower doses and titrate upward monthly, allowing physiological adaptation and reducing GI side effects. The physician determines the appropriate starting dose based on individual assessment.
Cyanocobalamin (B-12)
Vitamin B-12 is an essential cofactor in DNA synthesis and cellular energy metabolism. Its inclusion supports general metabolic function during the protocol and may help address common B-12 deficiencies in the population.

Available Options

Select the option appropriate for your current protocol stage. If you are new, begin with the starting dose. Your physician will guide progression based on your individual response and medical evaluation.


Month 1 · Starting Dose
Tirzepatide + B-12
2.5mg/0.5mL · 2mL Vial
$279.95
31g syringes ×10 · Alcohol wipes ×10
Begin Evaluation
Physician approval required

Month 2
Tirzepatide + B-12
5mg/0.5mL · 2mL Vial
$379.95
31g syringes ×10 · Alcohol wipes ×10
Begin Evaluation
Physician approval required

Month 3
Tirzepatide + B-12
7.5mg/0.5mL · 2mL Vial
$479.95
31g syringes ×10 · Alcohol wipes ×10
Begin Evaluation
Physician approval required

Month 4
Tirzepatide + B-12
10mg/0.5mL · 2mL Vial
$579.95
31g syringes ×10 · Alcohol wipes ×10
Begin Evaluation
Physician approval required

Month 5+
Tirzepatide + B-12
12.5mg/0.5mL · 2mL Vial
$679.95
31g syringes ×10 · Alcohol wipes ×10
Begin Evaluation
Physician approval required

Continuation Vial
Tirzepatide + Glycine
74.7mg · 4.5mL Vial
$899.95
31g syringes ×10 · Alcohol wipes ×10
Begin Evaluation
Physician approval required

What to Expect

After selecting an option above you will be directed to the TeleWellnessMD® platform. A licensed medical provider will review your health information and determine whether this protocol is appropriate for you. An initial consultation is required before any prescription can be issued. Prescription availability varies by state.

Results and side effects vary from patient to patient. These reports do not constitute medical claims.

Not Sure Where to Start?

Speak with a Licensed Provider

Start with a free physician assessment. A TeleWellnessMD® provider will evaluate your situation and recommend the appropriate protocol.

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Compounded medications are not FDA-approved as safe and effective for the treatment of any disease or condition. The FDA does not review compounded formulations for safety, effectiveness, or quality. Compounded medications are prepared by a state-regulated licensed pharmacy in accordance with a prescriber's order. Results and side effects may vary from patient to patient. The Vitality Stack is an advertising affiliate of TeleWellnessMD® and may earn a commission if you complete a purchase. This content is for educational and advertising purposes only and does not constitute medical advice. Consult a licensed physician before starting any medication protocol. TeleWellnessMD® physicians exercise independent professional medical judgment in all prescribing decisions.