Semaglutide B12 Protocol

Peptide Therapy› Weight Loss› Semaglutide + B-12
GLP-1 Receptor Agonist · Physician Services

Semaglutide + B-12

Compounded Injectable · Cyanocobalamin · Progressive Dosing Protocol
How this works: Select the dosing tier appropriate for your stage of protocol. Clicking any tier below takes you to the TeleWellnessMD® platform where a licensed medical provider reviews your information and determines whether this protocol is appropriate for you. An initial consultation is required before any prescription can be issued. Compounded medications are not FDA-approved as safe and effective for the treatment of any disease or condition.
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About This Protocol

Semaglutide is a GLP-1 receptor agonist — a compound that mimics the action of glucagon-like peptide-1, a hormone naturally produced in the intestinal tract in response to food intake. This protocol is compounded with Cyanocobalamin (Vitamin B-12) to support cellular energy metabolism throughout the protocol.

This is a physician-supervised compounded medication available exclusively through licensed TeleWellnessMD® medical providers. The physician evaluates each patient individually and determines medical necessity. Not all patients will qualify.

GLP-1 Receptor Mechanism
GLP-1 receptors are expressed in the pancreas, brain, stomach, and cardiovascular tissue. When activated, they stimulate insulin secretion in a glucose-dependent manner, reduce glucagon output, and slow gastric emptying. According to research published in the New England Journal of Medicine (2021), GLP-1 receptor agonists have been studied extensively for their effects on appetite regulation and metabolic signaling.
Cyanocobalamin (B-12)
Vitamin B-12 is an essential cofactor in DNA synthesis, neurological function, and the conversion of homocysteine to methionine. It plays a role in red blood cell formation and cellular energy metabolism. According to research in the American Journal of Clinical Nutrition, B-12 is involved in mitochondrial function and may support energy levels during caloric restriction protocols.
Progressive Dosing Rationale
Clinical protocols using GLP-1 receptor agonists typically begin at lower doses and titrate upward over multiple months. This approach allows the body to adapt to the compound and is associated with reduced GI side effects compared to immediate high-dose initiation. The physician determines the appropriate starting dose based on individual assessment.
Physician Determination
All prescribing decisions are made exclusively by licensed TeleWellnessMD® physicians based on their independent professional medical judgment. The physician reviews patient health history, current medications, and individual circumstances before determining whether this protocol is appropriate. Results and side effects vary from patient to patient.

Available Dosing Tiers

Select the tier corresponding to your current stage of protocol. If you are new to this protocol, begin with Month 1. Your physician will guide progression through subsequent tiers based on your individual response.

Starting Dose
Month 1
0.25mg/0.5mL · 2mL Vial
$199.95
Includes: 31g syringes ×10 · Alcohol wipes ×10
Begin Evaluation
Physician approval required
Month 2
Month 2
0.5mg/0.5mL · 2mL Vial
$249.95
Includes: 31g syringes ×10 · Alcohol wipes ×10
Begin Evaluation
Physician approval required
Month 3
Month 3
1mg/0.5mL · 2mL Vial
$299.95
Includes: 31g syringes ×10 · Alcohol wipes ×10
Begin Evaluation
Physician approval required
Continuation
Month 4+
1.7mg/0.5mL · 2mL Vial
$349.95
Includes: 31g syringes ×10 · Alcohol wipes ×10
Begin Evaluation
Physician approval required
Starter Vial
B-6 Blend
1mg/2mg/mL · 7mL Vial
$339.95
Includes: 31g syringes ×10 · Alcohol wipes ×10
Begin Evaluation
Select states only · Physician approval required
High Dose
5mg Vial
5mg/0.5mg per mL · 2.5mL Vial
$529.95
Includes: 31g syringes ×20 · Alcohol wipes ×20
Begin Evaluation
Select states only · Physician approval required

What to Expect

After clicking any tier above you will be directed to the TeleWellnessMD® platform. A licensed medical provider will review your health information and determine whether this protocol is appropriate for you. An initial consultation is required before any prescription can be issued.

Prescription availability varies by state. Some tiers are available only in specific states based on pharmacy licensing. Your provider will advise on which options are available in your location.

Some patients who have used GLP-1 receptor agonist protocols have reported changes in appetite, body composition, and metabolic markers. Results and side effects vary from patient to patient. These reports do not constitute medical claims.

Not Sure Where to Start?

Speak with a Licensed Provider

Start with a free assessment. A TeleWellnessMD® physician will evaluate your situation and recommend the appropriate protocol.

Start Free Assessment →
25% off your first order · Automatically applied · No obligation · Physician determines medical necessity

Compounded medications are not FDA-approved as safe and effective for the treatment of any disease or condition. The FDA does not review compounded formulations for safety, effectiveness, or quality. Compounded medications are prepared by a state-regulated licensed pharmacy in accordance with a prescriber's order. Results and side effects may vary from patient to patient. The Vitality Stack is an advertising affiliate of TeleWellnessMD® and may earn a commission if you complete a purchase. This content is for educational and advertising purposes only and does not constitute medical advice. Consult a licensed physician before starting any medication protocol.