B12 Injection Protocol

Physician Services›Energy & Wellness›B-12 Methylcobalamin
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Vitamin Supplement · Physician Services

B-12 Methylcobalamin

Compounded Injectable · High-Dose · Physician Supervised
How this works: Clicking any option below takes you to the TeleWellnessMD® platform where a licensed medical provider reviews your information. An initial consultation is required. Compounded medications are not FDA-approved as safe and effective for the treatment of any disease or condition.
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About This Protocol

Injectable Methylcobalamin (Vitamin B-12) provides direct systemic delivery of the active methylated form of B-12. Unlike cyanocobalamin found in most oral supplements, methylcobalamin is the form that directly participates in methylation reactions without requiring hepatic conversion.

Available through TeleWellnessMD® licensed physicians. Multiple concentration tiers available. Physician determines appropriate dosing and frequency.

Methylcobalamin vs Cyanocobalamin
Methylcobalamin is the active coenzyme form of B-12, directly involved in methionine synthesis and myelin formation. Cyanocobalamin requires hepatic conversion to methylcobalamin before it can be utilized. Injectable methylcobalamin bypasses this conversion.
Neurological Function
B-12 is required for myelin sheath synthesis — the protective coating on nerve fibers. Deficiency is associated with peripheral neuropathy and cognitive changes. Injectable delivery achieves higher serum levels than oral supplementation.
Methylation Cofactor
Methylcobalamin is a cofactor for methionine synthase, which converts homocysteine to methionine. Elevated homocysteine is associated with cardiovascular risk. B-12 sufficiency supports homocysteine regulation.
Absorption Advantage
Injectable B-12 achieves serum levels substantially higher than oral supplementation, which is limited by intrinsic factor availability in the gut. This is particularly relevant for patients with GI absorption issues or pernicious anemia.

Available Options

Select the option appropriate for your current protocol stage. If you are new, begin with the starting dose. Your physician will guide progression based on your individual response and medical evaluation.


Standard
B-12 Methyl
1,000 mcg/mL · 10mg Vial
$85.95
25g syringes ×10 · Alcohol wipes ×10 · Mix kit ×1
Begin Evaluation
Physician approval required

High Dose 50mg
B-12 Methyl Max
5mg/mL · 50mg Vial
$199.95
31g syringes ×20 · Alcohol wipes ×20
Begin Evaluation
Physician approval required

High Dose 62.5mg
B-12 Methyl Max
12.5mg/mL · 62.5mg Vial
$219.95
31g syringes ×10 · Alcohol wipes ×10
Begin Evaluation
Physician approval required

What to Expect

After selecting an option above you will be directed to the TeleWellnessMD® platform. A licensed medical provider will review your health information and determine whether this protocol is appropriate for you. An initial consultation is required before any prescription can be issued. Prescription availability varies by state.

Results and side effects vary from patient to patient. These reports do not constitute medical claims.

Not Sure Where to Start?

Speak with a Licensed Provider

Start with a free physician assessment. A TeleWellnessMD® provider will evaluate your situation and recommend the appropriate protocol.

Start Free Assessment →
25% off your first order · Automatically applied · TeleWellnessMD® · Physician determines medical necessity

Compounded medications are not FDA-approved as safe and effective for the treatment of any disease or condition. The FDA does not review compounded formulations for safety, effectiveness, or quality. Compounded medications are prepared by a state-regulated licensed pharmacy in accordance with a prescriber's order. Results and side effects may vary from patient to patient. The Vitality Stack is an advertising affiliate of TeleWellnessMD® and may earn a commission if you complete a purchase. This content is for educational and advertising purposes only and does not constitute medical advice. Consult a licensed physician before starting any medication protocol. TeleWellnessMD® physicians exercise independent professional medical judgment in all prescribing decisions.