5-Amino-1MQ Protocol

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NNMT Inhibitor · Physician Services

5-Amino-1MQ Protocol

Compounded Capsule · NNMT Inhibitor · Physician Supervised
How this works: Clicking below takes you to TeleWellnessMD® where a licensed medical provider reviews your information. An initial consultation is required. Compounded medications are not FDA-approved as safe and effective for the treatment of any disease or condition.
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About This Protocol

5-Amino-1-methylquinolinium (5-Amino-1MQ) is a small molecule inhibitor of Nicotinamide N-methyltransferase (NNMT) — an enzyme that metabolizes nicotinamide (Vitamin B3) and plays a role in NAD+ bioavailability and cellular energy regulation. By inhibiting NNMT, 5-Amino-1MQ may increase intracellular NAD+ levels.

Available through TeleWellnessMD® licensed physicians in select states (AK, AL, CA, LA, MA, MN, MS, NM, WA). Capsule formulation — no injection required. Physician evaluates appropriateness for each patient.

NNMT Inhibition Mechanism
NNMT catalyzes the methylation of nicotinamide, diverting it away from the NAD+ synthesis pathway. By inhibiting NNMT, 5-Amino-1MQ reduces this diversion, potentially increasing the availability of nicotinamide for NAD+ production via the salvage pathway.
NAD+ and Metabolism
NAD+ is a critical coenzyme in mitochondrial energy metabolism and a substrate for sirtuins and PARP enzymes involved in DNA repair and gene regulation. Research has examined compounds that raise NAD+ levels for their metabolic effects.
Adipocyte Research
Preclinical research has examined 5-Amino-1MQ in adipocyte (fat cell) models, looking at effects on lipid metabolism and fat cell differentiation. Studies have examined its potential influence on metabolic rate in cellular models.
Oral Capsule Advantage
Unlike injectable NAD+ precursors, 5-Amino-1MQ is an oral capsule — no injection required. This makes it accessible for patients who prefer non-injectable protocols or who are using it alongside other NAD+ support strategies.

Available Options

Select the option appropriate for your protocol. If you are new, begin with the starting dose. Your physician will guide progression based on individual response and medical evaluation.

Standard Supply
5-Amino-1MQ
50mg Capsule · 30 Count
$199.95
No supplies needed · Oral capsule
Begin Evaluation
Physician approval required

What to Expect

After selecting an option above you will be directed to the TeleWellnessMD® platform. A licensed medical provider will review your health information and determine whether this protocol is appropriate. An initial consultation is required. Prescription availability varies by state.

Results and side effects vary from patient to patient.

Not Sure Where to Start?

Speak with a Licensed Provider

Start with a free physician assessment. A TeleWellnessMD® provider will evaluate your situation and recommend the appropriate protocol.

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25% off your first order · Automatically applied · No obligation · Physician determines medical necessity

Compounded medications are not FDA-approved as safe and effective for the treatment of any disease or condition. The FDA does not review compounded formulations for safety, effectiveness, or quality. Compounded medications are prepared by a state-regulated licensed pharmacy in accordance with a prescriber's order. Results and side effects may vary from patient to patient. The Vitality Stack is an advertising affiliate of TeleWellnessMD® and may earn a commission if you complete a purchase. This content is for educational and advertising purposes only and does not constitute medical advice. Consult a licensed physician before starting any medication protocol.